Metabolomics

Metabolomics (also known as metabonomics or metabolic profiling) deals with the quantitative analysis of multicomponent mixtures of biological samples, and is focused on establishing metabolic responses of living systems to pathophysiological stimuli or genetic alterations.  While vast progress in the fields of genomics and proteomics have provided a wealth of information for understanding the factors that regulate cell physiology and pathology, great insight into the functions of biological systems is also gained through the study of concentrations and fluxes of metabolites.

The quantitative measurement of small molecule metabolites that are the end products of genes, transcripts and proteins functions provides vital information for understanding the composition and function of biochemical networks, and promises solutions to many important questions related to human disease diagnosis, prognosis and therapeutic development. Significant interest in the application of metabolomics-based approaches stems from an ability to detect and quantitatively analyze up to many hundreds of metabolites in parallel, which provides an efficient method for unraveling altered biochemistry, providing mechanistic understanding and even drug targets.  Since subtle changes in gene expression or protein levels can cause substantial changes in metabolite concentrations, analysis of metabolites represents a very sensitive measure of biological status. More importantly, metabolomics, through the fingerprinting of biological variations of individuals offers avenues to achieve the goal of “personalized medicine.”

 

Applications & Projects

Metabolomics applications are focused on applications in disease related biomarker discovery and for basic systems biology research. We work closely with a large number of clinical collaborators and biostatisticians on various metabolomics projects such as the identification of biomarkers for esophageal, breast, liver and colon cancer detection and for breast cancer recurrence monitoring. Cell based studies are focused on investigating disease related metabolic perturbations and determining metabolic mechanisms. We have strong interest in expanding the understanding of disease risk factors using metabolite profiling approaches.

Typical Projects:

  1. Cancer Cellular Biology
  2. Nutrition
  3. Cancer Biomarker Discovery
  4. Diabetes
  5. Heart Diseases
  6. Aging Studies
  7. Stem Cells
  8. Bio-transformation
  9. Mitochondrial Studies